Fery, 24, produced a career-changing run at the All England Club in July, propelling him into the world's top 40 for the first time and securing his US Open debut in the process.
Fery narrowly missed out on a seeding and, having been drawn against 2025 quarter-finalist Musetti, has received a tough opener as a result.
A lot of attention will be placed on how the world number 37 fares in New York, where he leads a rather sparse British contingent in the absence of injured pair Jack Draper and Emma Raducanu.
Draper, who reached the 2024 semi-finals, withdrew last week because of a long-term arm injury, while 2021 champion Raducanu remains sidelined with the shin fracture which also forced her to miss Wimbledon.
British men's number one Cameron Norrie did manage to sneak into the seedings and the 29th seed plays France's Luca van Assche in his opening match.
Jan Choinski is currently the only other Briton in the men's draw after reaching the world's top 100 for the first time in June at the age of 30.