Djokovic is now, once again, two wins away from claiming the standalone record for the most Grand Slam singles titles in history.
World number one Sinner, who defeated Jan-Lennard Struff earlier on Tuesday, will be hoping to derail the Serb's efforts in a repeat of last year's semi-final.
The Italian dismissed Djokovic effortlessly on Centre Court 12 months ago - a defeat that left the seven-time Wimbledon champion lamenting his age.
"I don't think it's bad fortune. It's just age, the wear and tear of the body," he said at the time.
But Djokovic, who claimed revenge on Sinner in the semi-finals of January's Australian Open, showed on Tuesday why he remains a Grand Slam contender by overcoming a man 14-years his junior in the toughest of durability tests.
After coming through the longest match of his career at Wimbledon, Djokovic stood with his arms aloft, soaking in the applause, before doing a dance routine in tribute to his daughter.