The Artemis crew are officially on their way in a historic 10-day mission around the Moon, which could take them further from Earth than anyone has ever been before.
The crew on the 10-day mission won't land on the Moon, but plan to circle it, while travelling further from Earth than anyone has ever been before. Following on from the unmanned Artemis I mission in 2022, Nasa's Artemis programme is preparing for deep-space missions - with an ultimate goal of reaching Mars in the 2030s.
Follow along with the BBC's live coverage of the launch here.