Assuming all the top teams make it safely through their groups - a dangerous assumption, admittedly - we shouldn't have to wait too long for some of the big hitters to collide.
It is in the last 16 where things could get really tasty, most notably with a potential tie between former champions Germany and France.
The pair last met in a World Cup at the quarter-final stage in 2014, with Mats Hummels' early header enough to send the Germans through.
If Germany come out on top again they would have to contend with the Netherlands and Spain if they are to reach the final - a very tough run having ended up in the most straightforward group.
On the other side of the draw, eyes will instantly be drawn to the quarter-final stage, with old rivals Messi and Ronaldo set for a possible showdown.
It would depend on both Argentina and Portugal finishing top of their respective groups and then squeezing through the last 32 and 16 but, if they are able to do that, it would be a remarkable way to mark the pair's final World Cups.
For England, a game against co-hosts Mexico seems the most likely last-32 tie, providing the Three Lions top their group.
And, if Scotland are able to get through, Japan or the Netherlands could be waiting for them in what would be their first ever World Cup knockout fixture.