The artwork was created to honour Rashford's 2020 child poverty campaign, when he spearheaded efforts to support children and families struggling with food and bills amid the challenges of the Covid-19 pandemic.
The forward, who has scored 17 times in 60 caps for England, was awarded a MBE for his efforts.
Around the corner from the mural is a busy side road lined by cafes and shops that flow into the heart of Withington. Among them stands the 'Mega Pound Store', its entrance lined with an assortment of footballs.
In 2020, Rashford reflected on BBC Breakfast about how his family once depended on places such as this.
He said: "I remember we used to go to a shop called Poundworld, we would schedule out the week.
"We would get seven yoghurts and you can have one a day. My mum did the best she could within the circumstances."
Rashford's connection to his roots and the values instilled during those challenging times resonate deeply with the people in the area.
"He is all about the community, he's loved here. He represents so much more than football, he represents a better world," said United fan and Withington local Nusaybah Rwifa.
"My mate used to be one of his coaches and every time I go round to his house and see the signed Rashford shirt he has, we always laugh. Rashford is a star here."