The Cardiff City Stadium will host Wales' visit from Denmark on Friday, 4 April before Italy visit Wales on Tuesday, 3 June at the Swansea.com Stadium.
Wales boss Wilkinson says sharing the matches around Wales will enable more supporters to watch.
"As we prepare for our first appearance in a major tournament, we felt that it was important to give the opportunity for our fans across the country to support and celebrate the team in the build-up to the Euros," she said.
"Playing in Wrexham, Cardiff and Swansea gives us the perfect opportunity to do so as we look to face tough but exciting opposition for the Nations League campaign. We can't wait to see the Red Wall turn up in their numbers for these huge games."
Venues have also been selected for Wales' away games with Wales visiting Monza in Italy on Friday, 21 February in their group opener, Gothenburg in Sweden on Friday, 4 April and Odense in Denmark on Friday, 30 May.